摘要
用NT—P—BSA—ELISA检测健康人及麻风病人血清中的特异抗体,结果显示其特异性为95.6％,敏感性在MB病人为92.7％,PB为50％。抗体水平以新发痛人最高,随着有效的治疗和病程延长,MB病人的抗体逐渐下降,病程达10年以上者多恢复到正常水平。而PB病人则在治疗的早期抗体已降至正常。对确定NT—P—BSA抗体的阳性阈值,我们比较了X+2SD和95％位数两种方法,以95％位数值作为阳性阈值较为合适。
NT-P-BSA ELISA has been used to determination of the specific antibody in the sera of leprosy patients and healthy persons.The results shpwed that its specifisity is 95.6% and the sensitivity 92.7% in MB and 50% in PB.The antibody level was highest in mewly detected cases,declining in MB as time went on and treatment was given,to normal level after over 10 years of the disease duration.And the level became normal even not long after the beginning of treatment in PB.The authors suggest that the percentile method in 95% is more suitable than X+2SD method for determination of threshold value in the test.
