摘要
作者对２０例胆固醇结石和１５例正常人的胆囊上皮细胞分泌颗粒和溶酶体进行了定量分析，同时测定其胆囊胆汁中的糖蛋白含量，比较两组间的差异。结果显示：结石组胆囊上皮细胞分泌颗粒数、体密度和总面积均明显高于对照组，而溶酶体含量则明显低于对照组；结石组胆汁中糖蛋白含量较对照组高，且胆汁中糖蛋白含量与细胞分泌颗粒数呈正相关，与溶酶体含量呈负相关。作者认为胆囊上皮细胞分泌颗粒影响胆汁糖蛋白量的变化，而溶酶体则可能与细胞内分泌颗粒或蛋白的降解有关，提示胆囊粘膜细胞内结构改变对结石形成起有一定作用。
The quantitative studies of secretory granules and lysosomes in gallbladder epithelium and gallbladder bile glycoprotein were performed in 20 gallstone patients and 15 gallstone-free subjects. The results showed that the number, the volume density and the total secretory granules were significantly increased in gallstone patients compared with gallstone-free controls. The gallstone patients had a markedly reduced number, volume density and total lysosome area compared with gallstone-free subjects. The glycoprotein concentration in gallbladder bile was increased up to 21.04 ±4. 92g/L in gallstone patients, as compare with 13. 02 ± 5. 72g/L (P＜0. 05) in the stone-free controls. The quantity of secretory granules and lysosomes was directly proportional to that of bile glycoproteins. Evidence and argument are presented suggesting that gallbladder epithelium secretory granules affect the concentration of bile glycoprotein and lysosome may be related to the intracellular degradation of secretory granules.
