摘要
测定１２只肝硬变大鼠肝组织的超氧化物歧化酶、总抗氧化能力及过氧化脂质水平，并与１２只正常大鼠肝组织相比较。结果显示：肝硬变大鼠肝组织的总抗氧化能力及超氧化物歧化酶水平明显降低，过氧化脂质水平明显升高。由此表明肝硬变肝脏对超氧自由基的清除能力下降，对缺血再灌注损伤的耐受性较差和对炎症、致癌物的敏感性增高。
The anti-oxidative ability of cirrhotic liver tissues was evaluated in rat models of cirrhotic liver which were induced by injecting carbon tetrachloride subcutaneously. The superoxide dismutase (SOD), general anti-oxidative ability (GAOA) and malonyldiadehyde (MDA) levels were determined in cirrhotic and normal rats. It was found that SOD and GAOA levels decreased (P<0. 05, P<0. 01)respectively and MDA level increased (P<0. 05) significantly in cirrhotic rat liver. The results suggest that cirrhotic livers have little ability to eliminate the superoxide free radicals as compared with normals and are more sensitive to is chemic--reperfusion or other in june.
