摘要
本文采用胃腔灌流法连续收集胃液,观察侧脑室注射（icv）加压素（AVP）对大鼠胃酸分泌的影响.结果表明:icvAvp（0.15单位）明显抑制胃酸分泌;预先icv阿托品（5ug）,心得安（10ug）,纳洛酮（5ug）均不影响Avp的抑酸作用;预先icv酚妥拉明（10ug）,则可阻断Avp的抑酸效应;切断双侧膈下迷走神经,Avp抑酸作用增强。以上结果提示:Avp抑制胃酸分泌是通过中枢α受体介导的。
Using the garage for continual collection of gastric Juice, the effect of intracere-broventricular (icv) injection of Arginine-Vasopressin(Avp) on gastric acid secretion was observed in rats. The results Showed that Avp(0.15u) decreased gastric acid output significantly. The decreas was not affalted by central administration of atropine (5ug) or propranolol(10ug) and naloxone (5ug) ,but abolished by phentolamine(10ug). After vagotomy the effect of Avp was remarkably increased. These results indicate that the inhibition effect of Avp on the gastric acid is induced by central adrenergic α-receptor.
出处
《咸宁医学院学报》
1995年第4期160-162,共3页
Journal of Xianning Medical College
