反复自然流产患者血清中封闭抗体的检测

Detection of blocking antibodies in sera of RSA

本文根据病史将反复自然流产(RSA)分类为原发性RSA 及继发性RSA,分别以单向混合淋巴细胞反应封闭试验及补体依赖微量细胞毒试验评价封闭抗体与两类流产的关系。结果发现,原发性RSA主要因封闭抗体缺乏所致;而继发性RSA 无封闭抗体缺乏迹象。因此,尽管原发性RSA 与继发性RSA 临床表现类似,但其免疫学病因及发病机理可能不同。

Recurent spontaneous abortion (RSA) was classified into the primary (1°) and the sec- ondary (2°) according to patients histoty.Occurence of blocking antibodies between them was investigated with mixed lymphocyte reaction—blocking assay and complement dependent cyto- toxicity assay.It was found that the primary abortion had been mainly caused by lack of block- ing antibodies,the secondary abortion without lack of blocking antibodies.Thus,the primary abortion is different from the secondary abortion in aspects of immune aetiology and immune mechanisms although their clinical manifestations are similar.