Gwe改善X射线诱变生成与IL—1

Improved effect of Gwe on mutagenesis in mice induced by X—ray & IL—1

Gwe 又名本草九甙,是一种来自中药的有效成份,是一种新型免疫调节剂。本文研究了Gwe改善小鼠X 射线诱变生成的作用,实验结果表明。Swiss 小鼠1.5Gy 全身照射后12小时,其骨髓细胞微核千分率、脾细胞染色体畸变率、脾细胞姊妹染色单体互换率均显著提高,Gwe 连续三天灌胃能使这三项指标均显著降低,其抑制率分别是40.6%、54.1%和29.5%。同时检测了脾细胞生成IL-1能力的变化,照射后12小时脾细胞生成IL-1的能力较生理盐水对照组相比有显著下降。Gwe 能促进脾细胞IL-1的产生用Gwe 处理的X 射线实验组与X 射线对照组相比有显著差异。IL-1样物质水平的变化与骨髓细胞微核千分率、脾细胞染色体畸变率的变化呈明显负相关。

Gwe is a new immunological response modifier extracted from traditional Chinese herbs.Inour experiments,We demonstracted that:1.Gwe could significantly inhibite micronucleus fre-quencies in mouse bone marrow cell and decrease both the chromosome aberration (CA) and Sis-ter— chromatid exchang frequencies of splenocytes in mice induced by 1.5Gy X—ray.2.itcould up—regulate the level of IL—1 like substance of splenocytes in mice induced by X—ray.3.there was negetive correlation between the level of IL—1 like substance in the cultured spleencell supernatant and micronucleus frequencies in bone marrow cells or CA frequencies in spleencells.