血清抗人染色体抗体的初步研究

A Preliminary study on serum Anti—Human—Chromosome Antibodies

以人染色体为抗原,用免疫金银染色(IGSS)与免疫荧光试验(IFT)相对照,自SLE 患者血清中检出抗人全染色体抗体(Ah ChrA)。其对SLE 的敏感性和特异性,IGSS 法分别为58.1%和98.5%,IFT 法分别为34.9%和99.5%;其阳性率及滴度与SLE 活动及肾损、免疫功能异常等密切相关。对与该抗体起反应的抗原成份亦进行了初步分析。

With human chromosomes,as antigen,anti—human—chromosome antibodies (AhChrA)were detected specifically from SLE patients sera by the methods of immunogold—silver staining(IGSS)and immnuofluorescenee tese (IFT)。To SLE,the sensitivity and specificity of serumAhChrA was 58.1%and98.5%respeetively in IGSS,34.9%and99.5%respectively in IFT。Boththe incidence and titer of AhChrA were found to be colsely related to the pathoactivity and thedamages of some important organs or tissues,such as kidney damage,abnormal immunity andhematocytopenia.A preliminary analysis of the antigen components reacting to AhChrA was alsoperformed。