风湿性心脏病IgM特异性激活补体类循环免疫复合物的研究

Circulating Igm—specific immune complexes activating complement in patients with rheumat IC heart disease

采用捕捉法ELISA,检测64例风湿性心脏病患者的IgM 特异性激活补体类循环免疫复合物(IgM/C_3—CIC),发现其阳性率与风湿活动、抗“O”及CRP 密切相关,而与年龄、性别、病程、RF、IgM、IgG、IgA、C_3、C_4及C_5无明显关系。这些结果提示,IgM/C_3—CIC 参与了风湿活动过程,风湿性心脏病是一种免疫调节紊乱性疾病。

Circulating IgM-specific immune complexes activating complement(IgM/C_3—CIC)weredetected in 64 cases of rheumatic heart disease by a complement types capture ELISA method.Itwas found that the positive rates of the specific immune cmplexes in patients with rheumatic ac-tivity(51.9%)were significantly higher than in patients without rheumatic activity(78.4%).Morever,the rates were closely related to antibody to streptolysin O and C reactive protein.butnot to sex、age、disease'time、IgM、IgG、IgA、C_3、C_4、C_5.These results suggest that immune modu-lation disorder is an essential factor of causing these relationships above,and circulating IgM— specific immune complexes activating complement pay an important role in rheumatic activity.