乙型肝炎患者可溶性白细胞介素2受体水平变化

Serum level of soluble interleukin-2 receptors in hepatitis B patients

本研究应用酶联免疫吸附试验(ELISA)检测了103例乙型肝炎各型患者及26倒乙肝病毒(HBV)携带者血清中可溶性白细胞介素2受体(sIL-2R)水平,并结合临床资料进行分析。结果发现:各型患者及HBV 携带者sIL-2R 水平均明显高于正常对照(P<0.01～0.001),其升高程度与病情轻重呈正比,在去除危重患者酶—胆分离时谷丙转氨酶(ALT)过低的影响后,sIL-2R 水平与ALT 有良好的正相关关系(r=0.38.p<0.05);作者认为sIL-2R 能够较好地反映疾病的活动状况,动态观察血清sIL-2R 水平的变化,对判断和评价HBV 感染后的病情演变及免疫失衡状态具有重要意义。

The level of serum soluble interleukin-2 receptor(sIL-2R)was measured in 103 patientswith hepatitis B and 26 hepatitis B virus(HBV)carriers by enzyme-linked assay.The sIL-2Rconcentration were elevated significantly in each type of hepatitis B patients and HBV carriers,compared with control group(P<0.01～0.001).The severe patients had the hightest sIL-2Rlevel(2426.80±972.50)and the patients with cirrhosis during the active phase and acute hepati-tis also had highter level(1403.76±524.30,1380.22±411.04).It indicated that sIL-2R par-alled the disease activity closely.Excepting the influence of enzyme-bilirubin seperation,sIL-2Rlevel correlated with ALT(r=0.38,P<0.05)which was considered a useful index of disease ac-tivity.The results suggested that serum sIL-2R level may reflect the severity of the disease andserve as an important immunoregulatory molecule that could be involved in madiating the im-munology disturbance in hepatitis B.