季节性面部接触性皮炎患者血清特异性IgE的研究

Determination of Serum Specific IgE in Patients with Seasonal Facial Contact Dermatitis.

用ELISA以花粉抗原对季节性面部接触性皮炎患者进行血清特异性IgE的检测并与非季节性面部接触性皮炎患者及健康人进行了比较。结果三组受试者血清特异性IgE阳性率差异有显著性意义(P<0.005)。季节组明显高于非季节组(P<0.005)及健康组(P<0.005),而非季节组与健康组差异无显著性意义(P>0.50)。结果表明:花粉是季节性面部接触性皮炎的重要致病因素,其发病机理与IgE介导的免疫反应有关。

The level of serum specific IgE was measured by using enzyme linked immunosorbent assay (ELISA) with pollen allergens in 41 cases of seasonal facial contact dermatitis (SFCD), 20 cases of nonseasonal facial contact dermatitis (NSFCD) and healthy controls. It was found that the positive rate for specific IgE was significantly higher in the SFCD group than that in the NSFCD(P<0.05) and control group (P<0.005), but the difference between the latter 2 groups was not significant (P>0.50). These results indicate that pollen is an important etiological factor of SFCD. The IgE mediated delayed cutaneous reaction may be involved in the pathogenesis of this disease.