三七总皂甙对动物脑缺血性损伤的保护作用

Protective Effect of Saponins of Panax Notoginseng on Cerebral Ischemia

观察三七总皂甙（ＳａｐｏｎｉｎｓｏｆＰａｎａｘｎｏｔｏｇｉｎｓｅｎｇＰＮＳ）对小鼠全脑缺血和大鼠局灶性脑缺血（ＭＣＡＯ）的影响。结果发现ＰＮＳ（５０、１００ｍｇ．ｋｇ－１×３ｄ，ｉｐ）明显延长断头或ｉｖ饱和ＭｇＣｌ２后喘息持续时间。ＰＮＳ２００ｍｇ．ｋｇ－１术前３０ｍｉｎ或ＭＣＡＯ术后１５ｍｉｎｉｐ能减少ＭＣＡＯ术后２４ｈ脑梗塞面积，改善神经功能障碍及行为异常，减轻神经细胞缺血性损害。提示ＰＮＳ对缺血性脑损伤有保护作用。

The effects of saponins of Panax Notoginseng (PNS) in complete brain ischemia and in rat middle cerebral artery occlussion (MCAO) model were studied in present paper,PNS (50,100 mg.kg -1 ×3d ,ip) significantly prolonged the duration of gasping of mice subjected to complete brain ischemia induced by decapitation or intravenous injection of MgCl 2. Treatment with PNS 200 mg.kg -1 ip was performed 30 min before or 15 min after MCAO. The infarcted area and the neurological deficit 24h following MCAO were reduced by PNS compared with the saline treated group.The neuronal injury determined by histopathological examination Was also attenuated.We could come to the Conclusion that PNS protect brain from ischemic damage.