血液光量子疗法对局灶性脑缺血大鼠大脑皮层局部血流量和脑水肿的影响

Effect of blood phototherapy on regional cerebral blood flow and cerebral edema in focal cerebral ischemic rats.

本文动态观测了光量子疗法治疗血栓栓塞性脑缺血大鼠,大脑皮层局部血流量(rCBF)及脑水肿的变化。结果:缺血6小时经光量子血液治疗2小时后,rCBF于注后30min明显增加,达19.78％(P<0.01),以后各点维持在一定水平,2小时增加到19.30(P<0.05)。脑组织比重:缺血中心区未见明显改善(P>0.1)而半暗区组织比重非常明显增加(P<0.001),可见水肿明显减轻。说明光量子疗法增加rCBF,减轻半暗区水肿。

The purpose of the present study was to dynamically observe the changes of regional cerebral blood flow(rCBF) and cerebral edema in the rats which were subjected to 2 hours of treatment of blood phototheraphy, thromboembolic brain ischemia for 6 hours. It was shown that the rCBF was increased by 19. 78% (P<0. 01) at 30 minutes after the treatment and then kept at a certain level. The rCBF was still increased by 19. 3%(P< 0. 05) at 2 hours after the treatment. Specific gravity of the cerebral cortex did not change significantly (P>0. 1) in the infarted areas and increased significantly (P<0. 001) in the penumbra areas. It was concluded that blood phototherapy could increase the rCBF and improve the penumbra edema.