L-茶氨酸的合成研究

Synthesis of L-Theanine

L 茶氨酸是绿茶的主要呈味成分 ,可由L 谷氨酸 γ 乙基酯 (Ⅰ)为原料 ,通过化学合成的方法得到。Ⅰ在吡啶溶液中与三苯基氯甲烷在 40℃下反应 48h ,接着与乙胺水溶液在室温下反应 48h ,再在乙酸水溶液中回流 5min脱去三苯甲基 ,得到L 茶氨酸 ,产率为 39% ,质量分数大于 98%

L Theanine,a major flavor component of green tea,was synthesized from γ ethyl L glutamate(Ⅰ).Ⅰ was tritylated with Ph 3CCl in pyridine at 40 ℃ for 48 h,treated with aq. EtNH 2 at room temperature for 48 h and detritylated with AcOH in H 2O under reflux for 5 min to give L theanine.The yield was up to 39%, w(L theanine)>98%.