房颤患者血小板膜糖蛋白Ⅱ_b/Ⅲ_a受体的变化及意义

Alterations and Significance of Platelet Membrane Glycoprotein Ⅱ_b/Ⅲ_a Receptor in Atrial Fibrillation Patients

目的 :探讨心房纤颤患者血小板膜糖蛋白 (GP)Ⅱb/Ⅲa 受体的变化及其临床意义。方法 :采用全血法流式细胞术(FCM )对 2 2例房颤患者静脉血中GPⅡb/Ⅲa 的含量进行检测 ,并与 2 6例窦性心律者对照。结果 :房颤患者血小板膜GPⅡb/Ⅲa 显著高于对照组 (P <0 .0 1) ;房颤患者中的持续房颤组高于阵发房颤组 (P <0 .0 1)。结论 :房颤引起血小板激活 ,激活程度可能与房颤持续时间有关。房颤患者处于血栓前状态。检测GPⅡb/Ⅲa 对评估房颤患者的栓塞危险性及指导抗凝、减少栓塞有重要意义。

Objective: To study the alterations and clinical significance of platelet membrane glycoprotein Ⅱ b/Ⅲ a (GP Ⅱ b/Ⅲ a) receptor in atrial fibrillation (AF) patients. Methods: Using flow cytometry (FCM), GP Ⅱ b/Ⅲ a were detected in 22 AF patients and 26 volunteer with sinus rhythm. Results: Platelet membrane GP Ⅱ b/Ⅲ a levels in patients with AF were significantly higher than those in controls ( P <0.01); GP Ⅱ b/Ⅲ a levles in patients with sustained AF were significantly higher than those in patients with paroxysmal AF ( P <0.01). Conclusion: AF activates platelets probably in a time dependent manner. Patients with AF are in a prethrombotic state (PTS). To detect the presence of GP Ⅱ b/Ⅲ a may be helpful in evaluating embolic risk and guiding anticoagulation for reducing embolic events in AF patients.