9例脑组织移植患者临床免疫学初步观察

Preliminary observation on clinicalimmunoreaction in 9 patients with brain transplantation.

本文观察了9例胎脑移植患者移植后的一般临床表现(首例移植迄今已有3年零9个月)。测定移植前与移植后外周血中的淋巴细胞计数(Lym)、淋巴细胞转化率(LTT)、血清免疫球蛋白IgG、IgA、IgM,补体C_3、C_4,抗核杭体(AnAb)等常规免疫指标。采用荧光抗体技术检测抗脑抗体。结果:在本组病人中未发现有临床免疫排斥反应(HVGR)和移植物抗宿主反应(GVHR)的临床表现。患者移植前、后的常规免疫指标测定值与正常人对照,无显著性差异(P>0.05)。仅有1例移植前、后抗核抗体均出现阳性反应,但滴度不变,都是1:20。患者移植前、后的荧光抗脑抗体检测也呈阴性结果。因此,初步认为,本组病例的移植免疫效应与“大脑为免疫特免器官”的论点相一致的。

We have observed the clinical symptoms of 9 patients with implanted fetal brain tissues (it's been 3 years and 9 months since the first fetal grafting operated)and measured the patients im-munological indexes such as peripheral blood lymphocyte,lymphocyte transformation percentage,IgG,IgM,IgA,C3,C4 as well as antinuclear antibody in pre-and post-transplantation.With fluorescent antibody technic the anti-fetal-antibody was also determined.It was indicated that host versus graft reaction (HVGR) and graft-versus-host reaction (GVHR) were not discovered in any patients after the transplantation.The im-munologic data of pre-and post-transplantation were not significantly different between the patients and the block controls (p>0.05).In antinuclear antibody test,only one patient was showed positive reaction,but both the reaction liters were same in pre-and post-transplantation (1:20).The antifetal antibody tests were negative.Our observations support that brain is an im-munologically privileged organ upon grafting immune response.