碱性成纤维细胞生长因子治疗外伤性鼓膜穿孔的疗效观察

EFFECT OF BASIC FIBROBLAST GROWTH FACTOR ON TRAUMATIC TYMPANIC MEMBRANE PERFORATION

目的 :观察局部应用碱性成纤维细胞生长因子 (BFGF)治疗外伤性鼓膜穿孔的效果。方法 :将外伤性鼓膜穿孔 31例分为两组 ,BFGF治疗组 (BFGF组 ) 2 1例 ,用碱性成纤维细胞生长因子配成 1%的溶液滴耳 ,对照组 10例用 0 .3%诺氟沙星滴耳液滴耳 ,两组均连用 10 d。结果 :1个月后 BFGF组 2 0例鼓膜穿孔均愈合 ,愈合率 95 .2 % ,平均愈合时间为 (10 .3±2 .2 ) d。对照组 6例愈合 ,愈合率为 6 0 % ,平均愈合时间为 (2 1.5± 4.6 ) d。两组愈合时间和愈合率比较 ,BFGF组明显优于对照组 (P <0 .0 1和 P <0 .0 5 )。结论

Objective: To explore the healing effects of basic Fibroblast Growth Factor(BFGF) on traumatic tympanic membrane(TM) perforation Methods: In 31 cases of traumatic TM perforation,21 patients were treated with 1% BFGF eardrop for ten days ,other 10 patients were in the control,in which the patients were administered with 0 3%Norfloxacin eardrop Results:After one month,complete closure of TM perforation was obtained in twenty ears treated with BFGF and the closure rate was 95 2%,compared with six ears of the controls and the closure rate was only 60% Average closure time was about ten days in BFGF gruop while in control gruop ,average closure time was about twenty one days The closure rate and healing time of traumatic TM perforation in BFGF group were higher and shorter than those in control group(P<0 05 and P<0 01) Conclusion:Local administration of BFGF was very benefitial to healing of traumatic TM perforation