词意分类与精神分裂症的事件相关电位

Semantic categories and event-related potentials in schizophrenics.

对19例精神分裂症病人的事件相关电位进行病例对照研究发现,精神分裂症N_(400)潜伏期较正常对照明显延长,波幅降低,这种差异在额区尤为突出。提示精神分裂症病人的语言发生机制及信息处理可能存在某种程度的障碍。

In this paper,the event-related potentials were examined both in normal controls and schizophrenics,which were evoked by using pictures as stimuli.We found that the wave N400 of event-related potentials could be evoked in both schizophernics and controls.The latencies of N400 were generally longer in schizophrenics than in controls.Meanwhile,schizophrenia had lower N400 amplitude,especially in left frontal area.Compared to the smooth patterns of N400 in controls,the N400 of schizophrenia were not smooth and split into two or three waves.It was suggested that there were impairments in semantic expectancies and a delay in information processing.Further discussions were also made in this paper.