乙型肝炎疫苗和卡介苗同时或分别接种的抗-HBs持久性

Study on Persistence of Anti-HBs of Separate or Simultaneous Administration of Hepatitis B Vaccine and BCG

对乙肝疫苗和卡介苗同时或分别接种的抗-HBs的持久性进行了研究。同时接种组(1组)和分别接种组(2、3A、3B组)的抗-HBs阴转率和GMT均无显著差异,提示乙肝疫苗和卡介苗可以同时接种。抗-HBs的持久性与全程免疫后抗-HBs的峰值呈正相关,峰值<100 mIU/ml者,3年后有43.48％抗体转阴。建议全程后抗-HBs<100 mIU/ml者,3年后宜加强一针。

Persistences of anti-HBs of separate or simultaneous administration of hepatitis B vaccine and BCG were studied. No significant difference was found between the positive rate of anti-HBs and GMT of person received the two vaccines simultaneously (group 1) and separately(group 2, 3A and 3B). The result indicated the two vaccines could be administered simultaneously. In addition, the persistence of anti- HBs positively correlated with the peak value of anti-HBs titer after completed a primary series of HB vaccination. Of the recipients whose peak value of anti-HBs titer<100mIU/ml,the negative conversion rate of anti-HBs after three years was 43. 48%. So this individuals should receive a booster dose 3 years after the completion of a primary series of vaccination.