摘要
目的:探讨胰岛素样生长因子Ⅰ（IGF-Ⅰ）在恶性肿瘤组织中的表达及其意义。方法:采用免疫组化法检测肝癌、大肠癌、鼻咽癌、乳腺癌和肺癌共160例患者及50名正常人相应组织中IGF-Ⅰ的表达情况。结果：IGF-Ⅰ在上述恶性肿瘤组织中的表达率分别为81.1%，46.9%，38.7%，23.3%和20.0%；在正常组织中的表达率分别为50.0%，0%，10.0%，40.0%和300%。肝癌组织中IGF-Ⅰ的表达明显高于其他恶性肿瘤和正常组织，并与血清AFP有一定关系。结论：IGF-Ⅰ在恶性肿瘤尤其是肝癌的发生演变过程中有重要作用。
To explore the biological significance and effect of the expression of IGF-Ⅰ in carcinoma tissuesMethod:Immunohistochemistry SP technique was used to determine the IGF-Ⅰ in 16 0 cases of carci noma tissues including hepatocellular carcinoma (HCC) , colorectal carcinoma , n asopharyngeal carcinoma , breast carcinoma , lung carcinoma , and in 50 subjects of normal tissuesResults:The expressions of IGF-Ⅰ were de tected in 81.1%、46.9%、38.7%、23.3% and 20%, respectively in tumor tissues , and in 50.0%,0%,10.0%,40.0%, and 30.0% in normal tissues The expression of IGF-Ⅰ in HCC was significantly highe r than that in the other tumor tissues and the normal tissues , and was strongly associated with serum AFPConclusion:IGF-Ⅰ may play an imp ortant role in the formation and development of malignant tumor , particularly i n HCC
基金
广西留学回国人员科学基金!(桂科回9632004)
