摘要
目的：研究黄体酮、他莫西芬、潘生丁、妇复春等药物对卵巢恶性肿瘤细胞耐药的逆转作用，以及观察应用体外敏感药物及其逆转药的临床治疗疗效。方法：用改进的MTT法检测33例卵巢恶性肿瘤细胞对6种常用化疗药物敏感性及其逆转耐药作用。结果：卵巢癌药敏的顺序为Taxol>DDP>ADM>VP16>PYM>CTX；逆转药对化疗药物逆转（增敏）的顺序为黄体酮>他莫西芬>妇复春>潘生丁。使用敏感药物及其逆转药治疗后，一年以上总有效率为78.78%，其中上皮癌为78.57%。结论：选择敏感化疗药物及其逆转药使治疗个体化，可提高卵巢恶性肿瘤的疗效；黄体酮、他莫西芬可直接增强抗癌效应，并逆转化疗药耐药性，能获得更好的疗效。
To investigate the reversional effect of p rogesterone et al on ovarian neoplasmas in vitro and therapeutic effects on pati ents with ovarian cancer treated with sensitive drug and reverse drug Method：Cytotoxic activity of 6 anticancer drug and reverse drug agains t ovarian neoplasms in vitro were observed by MTT method in 33 cases of ovarian cancerResults：(1),The order of sensitive drug against ovari an neoplasmas were Taxol>DDP>ADM>VP16>PYM>CTX; The order of reverse drug for inc reasing sensitive of these anticancer drugs were Progesterone>Tamoxife>Fu Fu Chu n>Persantin (2), The response rate of patients treated with sensitive anticanc er drug and reverse drug is 78.78%, of which epithelial ovarian cancer is 78.57%Conclusion：The response rate will be improved for pa tients with ovarian cancer by using sensitive anticancer drug and reverse drug i n individualized treatment
基金
广西卫生厅科技基金!(9613)
