急性脑血管病患者血清内源性洋地黄样因子变化的意义

Change of serum concentration of endogenous digitalis-like factor in patients with acute cerbrovscular disease

用放射免疫法测定41例急性脑血管病(ACVD)患者和50例正常人血清内源性洋地黄样甲子(EDF)浓度。结果显示:ACVD患者血清EDF浓度明显高于正常对照组(P<0.05),且与患者意识状态密切相关;提示EDF的变化可作为ACVD时病情危重程度的预测指标。血清EDF升高的原因,可能与ACVD时下丘脑——垂体系统受损和(或)机体的应激反应有关。

Serum concentration of endogenous digitalis-like factor(EDF)in 41 patients with acute cerebrovascular disease(ACVD)and 50 normal controls was deter-mined by radioimmunoassay.The result showed that se-rum EDF in these patients was signficantly higherthan that in the control group(P<0.005),with a goodcorrelation between serum EDF and the state of con-sciousness.Serum EDF level was closely related to theseverity of ACVD.It is quite possible that the increaseof serum EDF concentration caused by ACVD is relat-ed to the stress reaction and damage of hypo-thalamus-pituitary axis.