慢性肺心病患者血清内源性洋地黄样因子与相关因素的临床研究

Clinical study of serum endogenous digitalis-like factor and related factors in paticnts with chronic corpulmonale

用放免方法测定58例肺心病患者和41例正常人血清内源性洋地黄样因子(EDF)浓度。结果发现,肺心病急性发作期患者血清EDF浓度明显低于正常人(P<0.01),缓解期明显升高;血清EDF浓度与心功能不全严重性、PaC0_2呈明显负相关,与Pa0_2呈明显正相关(P分别<0.01、<0.05、<0.01);病程、肝、肾功能状态、血pH值对血清EDF浓度有明显影响(P<0.05～0.02)。

Serum concentrations of endogenous digitalislike factor(EDF)were determined by radioimmunoassay in 58 patients with acute attack of chronic corpulmonale(CCP)and 41 normal controls.The resultshowed that serum EDF of the patients with acute at-tack of CCP were markdely lower than those of thenormal controls(P<0.01),but markedly increasedduring the remission stage.Serum concentration ofEDF had a signifcantly negative correlation with the severity of heart dysfunction and PaCO2,and asignificantly positive correlation with PaO2(P<0.01,<0.05 and<0.01 respectively).The course of the dis-ease,the status of hepatic and renal function,andblood pH obviously affected the serum concentrationof EDF(P<0.05～0.02).