硫糖铝及营养液对大鼠应激性溃疡的影响

Effect of ulcerlmin on stress ulceration in rats

采用束缚-水浸法建立大鼠应激性溃疡模型,以胃粘膜缺损程度和胃内出血量改变为指标,研究硫糖铝及营养液[1.39mmol/L(25%)葡萄糖液,1.39mmol/L葡萄糖液加能量合剂,脂肪乳剂],对大鼠应激性溃疡形成中的影响。结果表明:硫糖铝、1.39mmol/L葡萄糖液对大鼠应激性溃疡具有显著预防作用,而1.39mmol/L葡萄糖液加能量合剂和脂肪乳剂均无预防作用。

Stress ulcer was induced in rats by binding and immerse-in-water method to investigate the changesof the degree of defect of the gastric membrane andthe amount of gastric bleeding which were used as in-dexes of the effect of ulcerlmin and nutrient solution(25% glucose solution and 25% glucose solution withenergy mixture and fat emulsion)on stress ulcerationin rats.The result showed that ulcerlmin with 25%glucose-solution had a significant preventive effect onstress ulceration in rats,whereas 25% glucose solutionwith energy mixture and fat emulsion had nopteventive effect.