小儿肺炎及肺炎心衰时血栓素B_2和6-酮-前列腺素F_(1α)的变化

Changes of thromboxane B_2and prostaglandin B_(1α)in children with pneumonia and associated heart failure/

对46例10个月～3.5岁肺炎患儿采用放免法测定血栓素B_2(TXB_2)和6-酮-前列腺素F_(1α)(6-酮-PGF_(1α))的含量以及两比值(T/K)的变化。对30例患儿进行了治疗前后的自身比较,并对重型肺炎(肺炎合并心衰)患儿与普通型肺炎进行比较。结果显示,肺炎急性期的TXB_2、6-酮-PGF_(1α)及T/K值明显高于对照组(P<0.01),恢复期下降,治疗前后比较差异显著(P<0.01)。肺炎心衰时TXB_2、6-酮-PGF(1α)及T/K比值明显高于普通型肺炎。结果表明,前列腺素系统在小儿肺炎急性期,尤其足重型肺炎的发生发展进程中参与了体内病生理变化并起了一定的作用。

46 Children with pneumonia were studied, Of these patients plasma levels of thromboxane B_2 (TXB2) and 6- Ketone- Pro＇staglandin F_(1a)(6- Keto-PGF_(1a)) were determinted by radioimmun- oassay. The twopparameters as well as thier ratio (T/K) were studied. In thirty cases, the parameters before and ofter medication were compared comparision was also made between the parameters of pneumonia with herat failure and the gnouy of group of common pneuomonie, The results showed that the levels of TXB_2, 6-Keo-PGF_(1a) and their (T/K) ratio were elevated significantly in patients with pneumonia the accute phase (P<0.01); at the recovery phase they declined. The TXB2and 6-Keto-PGF_(1a) levels before and after mediontion were significat and they were significantly higher in children with pneumonia asso- ciated with heart failure than those with common pneumonia The results suggest that the protasglandin producing system is closely related to the acute phase of pneumonia and particularly in the emergence and evolution of pneumonia related heart failure.