门体分流对肝脏及胰岛细胞功能的影响

Studies of Effects of Portasystemic Shunt on the Function of the Liver and the Pancreatic Islet Cells

本实验动态观察犬行门腔和肠腔端侧分流术后对肝脏和胰岛细胞功能的影响。分析两组分流术后肝脏形态学改变和门脉血中胰岛素浓度与肝血流量变化之间的关系后,作者认为肝血流量减少是肝功能恶化的主要因素,两组分流术后周围血和门脉血中胰岛素和胰高糖素水平均降低,且同时有胰岛A,B细胞数量减少和胰腺空泡变性等。上述变化门腔分流组较肠腔分流血为明显。由此提示,门体分流术,尤其是全门体分流术可损害胰腺内分泌功能。

The present study was aimed at dynamic observation of the effects of end to side portacaval shunt (PCS) and end to side mesocaval shunt (MCS) in dogs on the functions of the liver and pancreatic islet cells. After analysing correlation among the changes of plasma insulin level in the portal vein and hepatic flow, and the liver morphology after PCS and MCS, we conclude that the depletion of hepatic flow is the major factor in the deterioration of liver function. The levels of insulin and glucagon in both peripheral vein and portal vein were decreased after PCS and MCS. At the same time, there were depletions of the pancreatic islet A and B cells and vacuolar degeneration of the pancreas. The changes mentioned above are more significant in PCS than in MCS, suggesting that portasystemic shunt, especially total portasystemic shunt, might damage the pancreatic endocrine function.