慢性胃炎和胃癌患者细胞免疫功能的改变

The Changes of Cell Immunology in Patients with Chronic Gastritis and Cancer

本文对浅表性胃炎、萎缩性胃炎、萎缩性胃炎伴不典型增生和胃癌患者的细胞免疫功能进行了观察。结果表明三组慢性胃炎患者外周血OKT_4都显著低于正常人(P<0.05);萎缩性胃炎组和胃癌组的OKT_8显著高于正常人组(P<0.05);OKT_4/OKT_8比值,浅表性胃炎和萎缩性胃炎组低于正常人组(P<0.05),萎缩性胃炎伴不典型增生组和胃癌组非常显著低于正常人组。三组慢性胃炎和胃癌患者外周血NK细胞活力和ADCC活力均低于正常人组,但无统计学意义。研究表明从慢性浅表性胃炎、萎缩性胃炎、萎缩性胃炎伴不典型增生到胃癌的病理变化过程中,伴随着细胞免疫功能的改变。

The peripheral blood lymphocytes (PBL) of patients with superficial gastritis, atrophic gastritis, atrophic gastritis with dysplasia and gastric cancer were classified by monoclone antibody OKT_3, OKT_4, OKT_5, Leu-7, Leu-11b, and the NK, ADCC activity were detected. The results showed, OKT_4 in three kinds of chronic gastritis was lower than normal (P<0.05), OKT_8 in atrophic gastritis and gastric cancer was higher than normal (P<0.05), and OKT_4 /OKT_8 in all these diseases was lower than control (P<0.05), (P<0.01). The activity of NK and ADCC in chronic gastritis and gastric cancer was somewhat lower than normal control but without statistical significance (P>0.05). Viewing through superficial gastritis to atrophic gastritis to gastric cancer, we can see a significant stepwise decrease in OKT_4 and increase in OKT_8 with gradual decrease of (OKT_4/OKT_8 ) ratio. It is concluded that there is a change of the subgroups of T cells when gastritis progresses from superficial to atrophic to malignant transformation, but its significance remains to be clarified.