慢性肾脏疾病蛋白C含量测定

Plasma Protein C in Renal Disease

本文用放射免疫法测定39例正常人及58例慢性肾脏疾病患者的血浆PC含量。1.慢性肾炎普通型7例,PC平均值为2.657±0.44 mg/L,与正常对照3.24±0.4 mg/L比明显降低(P<0.05);2.肾病综合征6例,PC含量为6.446±2.504 mg/L,与对照组比明显升高(P<0.05);3.氮质血症组8例,PC平均值为3.424±0.363 mg/L,与正常对照比无明显差异(P>0.05);4.尿毒症非透析组26例,PC平均值为4.902±2.035 mg/L与正常比明显升高(P<0.001);5.尿毒症透析组,其中血透6例PC平均值为2.63±0.547 mg/L,与正常对照比明显下降(P<0.05),腹透组5例PC值为5.56±1.952 mg/L,与正常对照比明显升高(P<0.05),在慢性肾脏疾病中PC降低可有血栓形成促使肾病恶化,PC增高可有抗凝作用引起出血倾向,在肾病综合征中PC增高有助于对抗高凝状态。

Human protein C (PC) is a vitamin K dependent protein in plasma with anticoagulant and profibrinolytic effects. PC was measured by radioimmunoassay. Plasma concentration of PC determined in 39 healthy controls was 3.24±0.24 mg/L. The results of plasma PC determined in 58 patients with chronic renal diseases were as follows. (1) 2.657±0.44 mg/L in chronic glomerulonephritis (n=7), being significantly lower than in controles (P<0.05); (2) 6.446±2.504 mg/L in nephrotic syndrome (n=6) being significantly elevated as compared with controls (P<0.05); (3) 3.424±0.636 mg/L in renal insufficiency (n=8) showing no significant statisfical difference from that of controls; (4) 4.902±2.035 mg/L in uremia not treated with dialysis (n=26) significantly higher than controls (P<0.001); (5) 5.56±1.952 mg/L in uremic patients treated with peritoneal dialysis, significantly elevated as compared wiht controls (P<0.05); (6) 2.63±0.547 mg/L in 6 uremic patients treated with hemodialysis, being significantly lower than in controls (P<0.05). Reduced plasma PC level is associated with thrombotic tendency that may be related to progression of chronic renal disease. Elevated plasma PC level may have anticoagulant effect and induce a bleeding tendency. In ncphrotic syndrome, high plasma PC levle might help to counteract hypercoagulability.