日本大耳白兔自发汗腺癌组织病理学及超微结构观察

Histopathology and Ultrastructure of Sweat Gland Carcinoma of Japanese Big-ear Rabbit

目的 对 1例普通级日本大耳白兔自发皮肤肿瘤进行研究。方法 采用病理组织学HE染色法及电镜超微结构观察方法。结果 在光镜下可见兔自发汗腺癌癌细胞排列呈巢状 ,胞浆空 ,淡染 ,细胞核大 ,病理核分裂相多见。电镜下癌细胞排列 ,部分胞间可见到桥粒 ,细胞质内糖原及张力原纤维多见 ,其他细胞器少见 ,细胞核大且大小不等 ,核形状多不规则。

Objective To investigate the spontaneous skin carcinoma of Japanese big-ear rabbit. Methods Pathological histology HE staining and electron microscope were adopted.Results Under optical microscope, the carcinoma cells arranged in nest dwelling pattern with empty and understained cytoplasm. Big nuclei and pathologic mitosis could also be seen often. Under electron microscope, the carcinoma cells arranged tightly with desmosemes between some cells. Glycogen and tonofibril in cytoplasm were common,with little other organelle seen. Nuclei of carcinoma cells were big and various in size with irregular karyomorphism.Conclusion The skin carcinoma is spoutaneous sweat gland carcinoma.