摘要
测定了甲氟哌酸(Pefloxacin)的抗菌谱,临床分离致病菌敏感性和感染动物的保护作用。结果表明,甲氟哌酸对 G~+菌和 G~-菌均有良好的抗菌作用,对临床分离金葡菌的 MIC_(50)为0.39μg/ml,大肠杆菌为0.19μg/ml,变形杆菌和肺炎杆菌分别为0.78μg/ml和0.39μg/ml,绿脓杆菌为6.5μg/ml。甲氟哌酸的抗菌活性与氟啶酸和氟哌酸(Nofloxacin)相似。小鼠分别感染金葡菌、大肠杆菌、肺炎杆菌和绿脓杆菌的保护效果明显强于氟哌酸。
Pefloxaein is a new antibacterial agent with a broad—spectrum included in the kind of fluoroquinolone.Pefloxacin was compared with norfloxacin and pipemidic acid in a series of tests in vitro.Pefloxacin was found to be similar in activityto norfloxacin against gram—positive and gram—negative bacteria and to be more activethan pipe midic acid,erythromycin and gentamicin.In vivo effect,pefloxacin showsbetter effect to infected mice than norfloxacin.
出处
《中国新药杂志》
CAS
CSCD
1993年第1期14-16,共3页
Chinese Journal of New Drugs
关键词
甲氟哌酸
药理学
Pefloxacin
Antibacterial activity
Infected mice
