抗溃疡新药—国产奥美拉唑（奥克）的研究

STUDY ON A NEW AND CHINA MADE ANTI-ULCER DRUG OMEPRAZOLE

进行国产奥美拉唑(奥克)的研制,并与进口产品作了化学、药理、临床等多方面的对比。临床采用双盲、随机分组。有162例(包括37例胃溃疡及125例十二指肠溃疡)用奥克,118例用法莫替丁,还有47例用进口产品进行治疗。试验结果表明:奥克的4周溃疡愈合率(94.6%,94.4%)及总有效率(100%,98.4%)明显高于法莫替丁对照组;与进口产品相比,其化学、药理及临床等各方面均一致。

Omeprazole manufacture has been studied by the authors'Institute and the chemistry,pharmacology,clinical and other aspects of both domestic omeprazole(AOKE)and imported omeprazole(LOSEC)were compared,forthe purpose of comparison,a randomized double-blind clinical trial was carriedout.It composed of 2 groups of patients.One group consist of 34 gastric ulcerand 125 duodenal ulcer patients and they were treated with AOKE,the othergroup consists of 37 gastric ulcer and 128 duodenal ulcer patients and they weretreated with famotidine or LOSEC.The results show that the healing rate andtotal effective rate of the AOKE group are greatly higher than those of thefamotidine group,and there is hardly any differences between AOKE andLOSEC group.