摘要
通过多中心前瞻性研究,观察了进口曲马多胶囊、注射液、栓剂以及口服滴剂在223例癌症、急腹症和手术后疼痛患者的镇痛效果,并分别与相应剂型的强痛定、氨酚待因和安慰剂作了随机或自身对比研究。结果表明:进口曲马多的镇痛总有效率为85.7%,其中癌症疼痛为88.3%,急腹症痛为75.2%,手术后痛为78.3%。总不良反应率为50%左右。疗效优于强痛定和氨酚待因。
In a prospective multicentres study,the pain relief effects of Tramadol preparations including capsules,injections,suppositories,and oral drops,were observed in 223 patients of cancer,postoperation,and acute abdominal pain.Its pain relief effects were compared with those of AP-237,Acetaminophen andplacebo.The effective rates of tramadol are 85.70% for total pain relief,88.3%for cancer pain,75. 2% for actue abdominal pain,78. 3% for postoperationpain.Adverse effects were observed in 50% of patients.Analysis revealed thatthe pain relief effects of Tramadol are superior to those of AP-237,Ac-etaminophen and placebo.
出处
《中国新药杂志》
CAS
CSCD
1993年第2期30-34,共5页
Chinese Journal of New Drugs
关键词
曲马多
解热镇痛药
Analgesics
Tramadol hydrochloride
Cancer pain
Postoperative pain
Acute abdominal pain
