高血压病患者血浆凝血噁烷B_2、6-酮-PGF_(1α)的变化

THROMBOXANE B_2 AND 6-KETO-PGF_(1α) AND THE DEVELOPMENT OF HYPERTENSION

本文观察了60例不同临床分期的高血压病患者血浆凝血(口恶)B_2(TXB_2,血栓素B_2)、6-酮-PGF+(1α)的变化,结果表明,高血压病各期TXB_2均明显升高,Ⅰ期高血压组6-酮-PGF_(1α)亦明显升高,TXB_2/6-酮-PGF_(1α)比值仅轻度增加;Ⅱ、Ⅲ期高血压组6-酮-PGF_(1α)则明显降低,TXB_2/6-酮-PGF_(1α)比值显著增加。组间比较:Ⅱ、Ⅲ期高血压组较Ⅰ期高血压组6-酮-PGF_(1α)显著降低,TXB_2/6-酮-PGF_(1α)比值明显增加。说明从高血压病初期到Ⅲ期,均有TXA_2、PGI_2的异常改变,这些变化可能与高血压的持续发展有关。

The contents of TXB_2 and 6-keto-PGF_(1α) were measured by radioimmunoassay in the plasma of 60 patients of different stages of hypertension. The results indicated that the TXB_2 levels were significantly higher in each group of hypertension than that in the control. The 6-keto-PGF_(1α) contents were significantly increased, and the ratios of TXB_2/6-keto-PGF_(1a) mod erately increased in the mild hypertension group; but the 6-keto-PGF_(1α) contents were significantly decreased and the TXB_2/6-keto-PGF_(1α) ratios were significantly increased in the moderate and severe hypertension groups, compared with those in the control. These findings show that TXA_2 and PGI_2 may play important roles in the development of hypertension.