高糖摄入对易卒中型自发性高血压大鼠胰岛素抗性的影响

EFFECTS OF GLUCOSE-RICH DIET ON STROKEPRONE SPONTANEOUSLY HYPERTENSIVE RAT

易卒中型自发性高血压大鼠(SHRsp)的饮水中添加10%葡萄糖喂养4周,其血糖水平增加、胰岛素抗性恶化。同时血压明显升高,交感神经系统兴奋性增加,血胆固醇及甘油三酯增加,心脏重量和相对重量增加、心肌血管紧张素Ⅱ水平增加。相关分析表明胰岛素水平与体重、血压、血胆固醇、去甲肾上腺素、心脏重量和相对重量呈显著正相关。提示高糖摄取可增加心血管病危险因子,其机制与胰岛素抗性恶化有关。

This study was designed to observe the effects of glucose-rich diet on blood pressure (BP), serum lipid, glucose and insulin, plasma catecholamines, etc. in stroke-prone spontaneously hypertensive rat (SHRsp). When 7 week old SHRsp drank 10% glucose ad libitum for 4 weeks, compared with control, serum glucose level rose with further increase of insulin resistance. BP, serum cholesterol (Chol) and triglyceride (TG) increased. Plasma norepinephrine (NE) concentration reflecting sympathetic activity elevated. The heart weight (HW), the heart weight/body weight% (HW/BW%) and the angiotensin Ⅱ (AH) in myocardium increased as well. Insulin correlated positively with BW, BP, Chol, HW and HW/BW%. The results demonstrate that glucose-rich diet may increase cardiovascular risks of SHRsp, which is secondary to glucose-induced further increase of insulin resistance.