依那普利对充血性心力衰竭患者血浆儿茶酚胺和血淋巴细胞β受体的影响

EFFECTS OF ENALAPRIL ON PLASMA CATECHOLAMINE AND LYMPHOCYTE BETA-ADRENERGIC RECEPTORS IN PATIENTS OF CONGESTIVE HEART FAILURE

本文测定54例充血性心力衰竭(CHF)患者血浆儿茶酚胺[CA:包括去甲肾上腺素(NA)、肾上腺素(A)、多巴胺(DA)]和血淋巴细胞β受体密度(L-BAR),并以15例正常人作为对照。结果表明,CHF患者血浆CA显著增高,其中NA增高更为突出,可反映心功能的受损程度;L-BAR仅重症者显著降低;NA、A与L-BAR呈显著负相关。依那普利(Enalapril)治疗后,NA显著降低,A、DA和L-BAR无明显变化,心功能改善。

Plasma catecholamine [CA :noradrenaline (NA), adrenaline (A) and dopamine (DA)] and lymphocyte beta-adrenergic receptor density (L-BAR) were measured in 54 patients with congestive heart failure (CHF) and 15 healthy controls. The results showed that plasma CA in the CHF patients was much higher than that in healthy controls, and L-BAR in severe CHF patients was significantly lower, plasma NA and A were negatively related to L-BAR. After treatment by enalapril (EN), plasma NA was significantly reduced, while no significant changes were noted in plasma A, DA and L-BAR, meanwhile the cardiac function was improved.