患者活体组织分离的特殊真菌的药敏实验

Drug-sensitivity Test of Anti-fungal Agents Against Special Fungi Isolated from Patients' Biopsy Specimens

本文采用药基点种法对从患者活体组织中分离的马尔尼菲青霉、微小根毛霉、球形阜孢霉以及1例罕见的全身性皮肤癣菌病的病原菌红色毛癣菌等进行了抗真菌药物的敏感性实验。结果显示:酮康唑、制霉菌素、的康唑和益康唑对4种真菌的抑菌效果优于其他抗真菌药物,如酮康唑对4种真菌MIC分别为1.56、6.25、25、3.13μg/ml,而大蒜素、克念菌素、5-氟胞嘧啶、十一烯酸锌的抑菌效果较差。

In vitro drug-sensitivity tests were performed to evaluate the effect of anti-fungal agents against Penicillium marneffi, Rhizomucor pusillus and Athrinium phaeospermum isolated from patients' biopsy specimens and Trichophyton rubrum isolated from a rare case of systemic dermatomycosis by the drug basic method. The results indicated that the anti-fungal effects of ketoconazole, nystatin, tioconazole and econazole were stronger than that of other anti-fungal agents. Allium, cannitracin flurocytosine and zinc undecenoate had little effect against above-mentioned four special fungi.