国产头孢氨苄片的溶出度比较

A Comparison of Dissolution Rates of Domestic Cephalexin Tablets

本文采用转蓝法测定了国内5个厂家的头孢氨苄片的溶出度,实验数据用单指数分布函数拟合,求得溶出速率常数ki值,并对ki值进行方差分析。结果表明:不同厂家的ki值有非常显著的差异(p<0.01)。

The dissolution rates of the cephalexin tablets made by five t actories in China were determined with rotating basket method. The dissolution constants Ki were calculated using single exponential method. The analysis of variance was carried out for Ki. The results showed that constants Ki of products from different factories were significantly different (p<0.01).