钙调素拮抗剂对非酶体系中羟自由基水平影响的研究

Effect of Calmodulin Antagonists on the Levels of Hydroxyl Radicals in a Non-Enzyme System

研究了钙调素拮抗剂，与抗坏血酸体系产生的羟自由基（．ＯＨ）的相互作用。结果显示，小檗胺（Ｅ０）及其衍生物（Ｅ５、Ｅ６）、蝙蝠葛碱（Ｄ１）及氯丙嗪（ＣＰＺ）在高浓度时均有清除．ＯＨ的作用；除Ｅ０和ＣＰＺ外，其它药物在低浓度均可促进．ＯＨ的生成。研究表明，研究钙调素（ＣａＭ）与自由基的相互关系时，在合理的浓度范围内使用ＣａＭ Ａ作为研究手段是可行的。

This article deals with the effect of Calmodulin antagonists (CaM A) on the levels of hydroxyl radicals ('OH) in a non-enzyme system. According to the result, Berbamine (E_0) and its derivatives (E_5, E_6), Dauricine (D_1) and Chlorpromazine (CPZ) can decrease 'OH level when at high concentration. All compounds tested can stimulate the formation of 'OH when at low concentration except for E_0 and CPZ. We draw a conclusion that using CaM A as a tool is practicable when studying the relationship of calmodulin and hydroxyl radicals.