摘要
苦豆碱抑制低浓度花生四烯酸(AA)和胶原诱导的兔血小板聚集,IC_(50)分别为184μg·L^(-1)和38.3mg·L^(-1)提高AA浓度使其抑制作用明显减弱。苦豆碱还抑制兔血小板形成血栓素B_2(TXB_2),此作用可能和其对血小板聚集的抑制有关。
The effect of aloperine on rabbit platelet aggregation was studied by Bern's method. The results showed that aloperine strongly inhibited platelet aggregation induced by low concentration of arachidonic acid (AA) or collagen with IC50 l84 μg · L-1and 38. 3 mg ·
L-1, respectively. The inhibitory effect of aloperine was evidently abolished by raising the concentration of AA. It was also showed the 10 ~ 100 mg · L-1 aloperine obviously reduced the production of TXB2. This action is possibly related to inhibited platelet aggregation by aloperine.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第2期138-139,共2页
Chinese Pharmacological Bulletin
