牡荆子脂质对实验动物气道平滑肌的影响

Effects of lipoid from mujingzi on smooth muscles of trachea in animals

观察牡荆子脂质对实验动物气道平滑肌的影响,结果表明;①牡荆子脂质可使通过小鼠肺支气管的灌流液流速明显增加,其增加程度与牡荆子脂质剂量呈依赖关系.此外,牡荆子脂质对ACh介导的小鼠气道平滑肌收缩有拮抗作用②给豚鼠牡荆子脂质(100～300 mg·kg^(-1)iP,可使由ACh+组胺喷雾引起的喘息潜伏期明显延长.牡荆子脂质对小鼠气道平滑肌的最佳扩张效果是其中油酸、亚油酸、棕榈酸和硬脂酸协同作用的结果.

The effects of Lipoid of Mujingzi 〔LP,Fruits of vitex neguando L Var cannabifo- lia (Sieb et Zucc) Hand mazz〕 on Smooth muscles are reported. The results were as follows:① In the isolated perfused mice lung-bronchi, LP caused significant increase of perfusion medium dropping through the lung-trachea, and the effect of LP was dose-dependent; ACh (Acetyl-choline)-induced contraction of the isolated mice trachea smooth muscles could be relaxed by LP. ② When LP was given introperitoneally(100~ 300 mg·kg-1) into guinea pig, the incubation period of asthma induced by acetycholine together with histamine was prolonged. The optimum dilated effect of LP on smooth muscles of trachea in mice can be concluded as the results of synergistic effects by 4 compositions from LP (Oleic acid,Linoleic acid, Palmitic acid and Stearic acid).