摘要
白芍总甙(TGP)每日ig 50mg·kg^(-1),连续7d可延长正常大鼠慢波睡眠(SWS)的持续时间.并能使咖啡因(12.5 mg·kg^(-1),ip)诱导的失眠大鼠睡眠各参数恢复到接近正常水平。TGP 50mg·kg^(-1)×3d)还可明显延长游泳大鼠(水温25±1℃.游泳时间30min)SWS和异相睡眠的总时间。上述实验结果提示TGP可改善不同功能状态下的大鼠睡眠。
Total glucosides of paeony (TGP, 50 mg/kg 7d, ig) could enhance the episode duration of slow-wave sleep (SWS) in normal rats, and restore the sleep parameters in the insomniac rats induced by caffeine ( 1 2. 5 mg/kg 7 d,ip)nearly to the normal level. It (50 mg/kg 3 d,ig) also increased significantly the
total time of SWS and paradoxical sleep (PS) in the swimming rats (water temperature 25±1℃, swimming time 30 min). These results suggest that TGP probably improve the sleep of rats under the different states.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第6期454-457,共4页
Chinese Pharmacological Bulletin
