丹皮酚的镇痛作用和无耐受性研究

Studies on the analgesic action and no tolerance of paeonol

本文用热板法、扭体法和甲醛致痛法,证实丹皮酚对小鼠有明显的镇痛作用。连续给小鼠皮下注射丹皮酚7d.每日用热板法测试小鼠痛阈,表明其镇痛作用无耐受现象。给小鼠皮下注射丹皮酚.竖尾反应与跳跃反应实验均呈阴性。用热板法测定.丹皮酚的镇痛作用不被纳洛酮翻转。用大鼠光热甩尾法,表明利血平能降低丹皮酚的镇痛效应。

Paeonol is an nerb which has been used us an anodyne. The analgesic action of Paeonol has been shown in this paper by using the following methods: Mice licking hind paw on hot plate (55℃); mice wring evoked by ip 0. 7% acetic acid 10 ml · kg-1; continuous pain stimuli elicited by sc 2. 5% formaldehyde 0. 03 ml in fore paw of mice. No tolerance of analgesic effect was found after daily sc of Paeonol 100 mg · kg-1for 7 d in mice assayed with hot plate method. In naloxone-challenge test, no jumping response was observed in mice treated with Paeonol 690 mg · kg-1, the maximal tolerance dose. The results indicate that Paeonol induced no morphine-like tolerance norphysical dependence. The analgesic action of Paeonol was not an-tagonizd by naloxone, but was eliminated by in-traperitoneal injection reserpine 3 mg · kg-1 3 h prior to Paeonol. These results demonstrate that Paeonol belongs to the non-narcotic analgesic, and suggested that the analgesic action of Paeonol may be related to the monoamine level in brain.