磺化铝酞菁对小鼠肿瘤和细胞膜的光动力作用

Photodynamic action of aluminum sulfonated phthalocyanine on murine tumor and cell membrane

磺化铝酞菁(AlSPC)合并铜激光泵浦染料激光器激光或红光照射,对小鼠S180肿瘤有显著光动力治疗作用,抑瘤率分别为62.7％和66.8％,AlSPC合并照光10 min,红细胞溶血度显著增加,AlSPC和20μg·ml^1合并照光10 min,使红细胞膜脂质过氧化大大加强,红细胞膜乙酰胆碱酯酶活力明显减低,使鼠肝线粒体ATP酶和微粒体葡糖-6-磷酸酶活力明显受抑,AlSPC对小鼠皮肤光敏反应持续时间短。

Mouse S180 tumor was markedly inhibited by aluminum sulfonated phthalocyanine(AISPC)plus dye laser pumped by pulse copper laser(630 nm)or red light exposure.Red cell membrane acetylcholinesterase.mitochondrial ATPase and microsomal G6Pase of the mouse liver were greatlyinactivated by AISPC plus light.