氟尿嘧啶在兔体房水内的药动学研究

Pharmacokinetics of fluorouracil in humor aqueus by subconjunctival injection in rabbits

本文研究了５－ＦＵ对兔结结膜下给药后，房水中５－ＦＵ的药动学，并介绍了一种非常实用的房水采集方法，为研究药物在房水中的药动学找到了一种科学的手段。研究结果显示：５－ＦＵ在房水中Ｔ１／２＝２７±２．６ｍｉｎ，Ｃｔｐｋ＝１９．６±７．１μｇ／ｍｌ，血中５－ＦＵ浓度在２μｇ／ｍｌ以下，提示在此剂量时（总剂量３ｍｇ／ｄ），５－ＦＵ只在眼部浓度较高，而对全身无毒副作用。

We studied pharmacokinetics of fluo-rouracil in humor aqueus by subconjunctivalinjection in rabbits. Useful method of collect-ing humor aqueus was used. 5-FU of half-livesin humor aqueus after subconjunctival injec-tion was 27.1±2.8min, peak concentration19.6±7.8mg/L, and 5-FU concentration inserum less than 2 mg/L. The resutls showedthat only 5-FU concentration in tested eye washigher after subconjunctival administration of3mg daily, which avoids general body reac-tion.