摘要
本文研究了5-FU对兔结结膜下给药后,房水中5-FU的药动学,并介绍了一种非常实用的房水采集方法,为研究药物在房水中的药动学找到了一种科学的手段。研究结果显示:5-FU在房水中T1/2=27±2.6min,Ctpk=19.6±7.1μg/ml,血中5-FU浓度在2μg/ml以下,提示在此剂量时(总剂量3mg/d),5-FU只在眼部浓度较高,而对全身无毒副作用。
We studied pharmacokinetics of fluo-rouracil in humor aqueus by subconjunctivalinjection in rabbits. Useful method of collect-ing humor aqueus was used. 5-FU of half-livesin humor aqueus after subconjunctival injec-tion was 27.1±2.8min, peak concentration19.6±7.8mg/L, and 5-FU concentration inserum less than 2 mg/L. The resutls showedthat only 5-FU concentration in tested eye washigher after subconjunctival administration of3mg daily, which avoids general body reac-tion.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1993年第11期672-674,共3页
Chinese Pharmaceutical Journal
关键词
氟尿嘧啶
房水
药物动力学
fluoroueacil
humor aqueus
pharmacokinetics