环孢素A在肾移植患者的药物动力学研究及临床血药浓度监测

Pharmacokinetics and blood concentration montoring of cyclosporine A in patients with renal transplantation

本文采用荧光偏振免疫（ＦＰＩＡ）法测定环孢素Ａ（ＣｓＡ）的全血浓度。测定对象为肾移患者３７例，其中５例患者口服ＣｓＡ后进行药代动力学研究，按口服吸收二房室模型计算药代动力学参数。结果表明患者之间存在着显著的个体差异。同时我们还对３７例肾移植患者进行１６９次临床血药深度监测。结果也表明患者个体之间差异较大。对制定给药方案、肾毒性和排斥反应的鉴别，以及药物相互作用影响。

Blood concentration of cyclosporine Awas determined by fluorescence polarizationimmunoassay in 37 patients receiving renaltransplantation. Pharmacokinetic was ob-served in 5 of the patient after oral administra-tion of cyclosporine A. The pharmacokineticparameters were calculated by two-compart-ment modle of oral adiministration absorp-tion. The results show that there are obviousindividual difference in the patients. Bloodconcentration of cyclosporine A was deter-mined for 169 times in all the patients. Theresults also show the individual diffference.We conclude that a to monitor of blood conce-tration of cyclosporin? A is important to de-cide drug administration, to make differentialdiagnosis between renal toxicity of the drugand rejection reaction and to know the interac-tion of drugs.