西洋参茎叶三萜皂甙的化学研究

Triterpenoid saponins in stems and leaves of American ginseng

为了利用引种的西洋参茎叶资源，创制新药，特进行此顶研究，将茎叶的水煮液，经大孔树脂吸附，以乙醇洗脱除杂质后得总皂甙。再用硅胶柱层析分离和纯化，共分得９种化合物。分别进行理化性质试验和光谱测定，经与对照品对照，鉴定为人参皂甙－Ｒｂ２，－Ｒｂ３，－Ｒｄ，－Ｒｅ，－Ｆ２，－Ｒｇ１，－Ｒｈ１，－Ｒｈ２和拟人参甙－Ｆ１１等，其中－Ｒｈ１－Ｒｈ２和Ｆ２系首次从核植物中获得。

We investigated the stems and leaves ofAmerican ginseng. The dried stems and leaveswere extracted with H_2 0,and the extracts weresubject to chromatography on a Macro-reticu-lar Resins column, eluted with alcohol. Crudesaponins were obtained after purifizction.From the crude saponins, 9 compounds wereisolated chromatographically on a silica gelcolumn. According to physical and chemicalconstants and spectrum data, along with com-parition with authentic samples, these com-pounds were identified as ginsenoside-Rb_2,-Rb_3,-Rd,-Re, -F_2, -Rg_1,-Rh_1,-Rh_2, andpseudo-ginsenoside-F_(11). Among them, ginseno-side-Rh_1,-Rh_2 and -F_2 were first isolatedfrom the stems and leaves of this plant.