慢阻肺继发性肺动脉高压与血栓素A_2、前列环素的关系

THE RELATIONSHIP BETWEEN TXA_2/PGI_2 AND PULMONARY HYPERTENSION IN PATIENTS WITH COPD

以10名慢阻肺继发性肺动脉高压患者和10名健康人为对象,采用右心漂浮导管的实验方法并应用放免技术,观察了肺血流动力学、动脉血气各指标和TXB_2、6-KPGF_(1α)的相关性。结果表明:慢阻肺患者血浆TXB_2水平高于健康人,6-KPGF_(1α)低于对照组,TXB_2/6-KPGF_(1α)比值明显升高。PAMP与血浆TXB_2、TXB_2/6-KPGF_(1α)比值呈正相关。PaO_2与TXB_2、TXB_2/6-KPGF_(1α)呈负相关,与6-KPGF_(1α)呈正相关。提示慢阻肺可能由于低氧使TXB_2/6-KPGF_(1α)比值升高,后者可能是收缩肺血管、引起肺动脉高压的因素之一。

We measured TXB_2, 6-KFCF_(1α) concentration in perpheral venous blocd in 10 patients with COPD who undeiwent cardiac catheterization. The results showed that TXB_2 (173±83pg/ml) was significantly higher than the values in 10 normal sub(?)ects (127±48pg/ml,P<0.05), 6-KPGF_(1α) (73±27pg/ml) was lower than the controls (135±70pg/ml, P<0.05) .Bcth TXP_2 and TXB_2/6-KPGF_(1α) correlated well with PAMP and TPVR, showed inverse correlation with PaO_2