几种新的肿瘤标志物对原发性肝癌的诊断价值

THE VALUES OF NEW CARCINOMA MARKERS IN THE DIAGNOSIS OF PRIMARY HEPATIC CANCER

本文通过47例原发性肝癌(PHC)、40例良性肝病、6例胃癌肝转移患者及正常对照30例,同时检测血清甲胎蛋白(AFP)异质体、唾液酸(SA)和5′核苷酸磷酸二脂酶同工酶(5′NPD),并与血清AFP值对照,结果:AFP异质体、SA和5′NPD对PHC的敏感性分别是82.98%、78.72%和87.23%;而特异性分别是90.0%、82.5%和75.0%。三者在APP阴性的PHC中诊断阳性率分别为78.26%,73.91%和86.96%。如4项指标联合检测可使PHC的诊断敏感性达到93.62%,特异性增加到90%。

Alpha-fetoprotein (AFP) variants, sialic acid and 5′nucleotide phosphodiesterase isoenzymes (5′NPD)were foundas new carcinoma markers, recently. They were studied in 123 sera including 47 patients with primary hepatic cancer (PHC), 40 patients with liver benign disease, 6 patients with hepatic metastasis of gastric cancer and 30 normal controls.Accoding to statistics, sensitivity of AFP variants, sialic acid and 5′NPD-Ⅴ, Ⅵ band to PHC were 82.98%, 78.72%and 87.23%。Spectficity of them were 90.0%, 82.5%and 75.0%. In 23 PHC patients with negative AFP, positive rate of them were 78.26% 73.91% and 86.96%. The detection of serum AFP, variants of AFP, sialic acid and 5′NPD at the same time might be helpful in the diagnosis.