糖类抗原CA-50对肿瘤诊断的价值

Diagnostic Value of CA-50, Carbohydrate Antigen in the Neoplasms

应用^(125)Ⅰ标记CA-50单克隆抗体的放射免疫抑制试验,检测37例恶性肿瘤患者、9例良性肿瘤、27例非肿瘤患者及30例正常人血清CA-50含量。其中正常人血清CA-50含量为6.03±1.15u/ml,原发性肝癌组为19.3±12.8u/ml,胰癌组为18.5±10.0u/ml,其他消化道癌肿为14.05±12.07u/ml,与正常对照组相比均明显升高(P<0.001)。良性肿癌组为5.32±2.12u/ml,接近正常对照组。另外,本组有4例原发性肝癌栓塞后,随着肿瘤缩小,其血清CA-50由高值转为阴性。综上所述,血清CA-50可作为恶性上皮类肿瘤诊断、鉴别诊断、疗效观察及判断预后的一项指标。

Carbohydrate antigen CA-50 increased in the body fluid and tissues while the patients with epithelial malignant tumors is a goo label for tumors. Radioimmuno-inhibitory assay by the use of [125]~1-1 labeled CA-50 mondclonal antibody was applyed in 37 cases with maignant tumor, 9 cases with benign tumor, 27 cases with no tumors and 30 cases of health control. The results indicated that serum CA-50 might be used as an index in the diagnosis, differential diognosis, therapeutic evaluation and prognosis for the epithelial malignant tumors.