中期和晚期乳腺单纯癌癌细胞形态参数的逐步判别分析

STEPWISE STATISTICS ANALYSIS OF MORPHOLOGICAL PARAMETERS IN MID STAGE AND LATE STAGE OF SIMPLE CARCINOMA OF BREAST

用体视学方法分别对 2 0例中期和 2 0例晚期乳腺单纯癌癌细胞、细胞核、核仁的 17个形态参数进行了测定和分析 ,并用逐步判别分析法筛选出 3个最佳参数 ,建立了判别函数。研究发现 ,与正常细胞比较 ,癌细胞比表面明显减小 ,晚期癌最小 (即细胞体积最大 ) ,同时癌细胞核体积和周长明显增大 ,晚期癌最大 ,这表明癌细胞及癌细胞核的体积越大 ,癌细胞核周长越长 ,癌细胞恶化程度越高。

Stereologic method was applied to analyse 17 morphological parameters of breast carcinoma cells, nuclei and nucleolus in 20 cases with breast carcinoma simplex. At last, the best three parameters were obtained and distinguish function was set up with mathematics statistical stepwise method. The result showed that compared with normal cell the specific surface of the cancer cells were obviously decreased, the specific surface was least in the late stage in breast carcinoma (the volume of the cancer cells were most). Synchronously the volume and perimeter were obviously increased in breast carcinoma and were most in the late stage in breast carcinoma. All these results mentioned above the greater the volume and the perimeter of cells and nucleus in breast carcinoma, the higher the degree of the cancer cells depravation.