摘要
以α-氰基丙烯酸正丁酯(BCA)为囊材采用均匀设计方案,筛选了阿糖腺苷毫微囊(Ara-A-Nc)的制备工艺,制品稳定性较好。Ara-A-NC 荷负电,加入电解质后荷正电,包封率为43.6%。药理结果表明,脑内 HSV-Ⅰ型病毒感染的小鼠,ip Ara-A-NC 50～100mg/kg,与 Ara-A 溶液对照组比较,更能延长存活时间。
Vidarabine nanocapsules (Ara-A-NC) were produced by a inter-
facial polymerization process with butyl α-cyanoacrylate(BCA).The suspension
obtained was stable at ambient temperature and could be sterilized by autoclavi-
ng.The encapsulation efficiency of Ara-A-NC was 43.6%.Antiviral results showed
that Ara-A-NC was more effective than Ara-A injection on experimental intrace-
rebral HSV-I infection in mice.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1993年第6期263-266,共4页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金
关键词
阿糖腺苷
毫微囊
制备
微型
胶囊剂
vidarabine
nanocapsules
preparation
antiviral activity
